CURRICULUM VITAE NAME: Levtchenko Elena Born: 3th of April 1965 in Moscow Nationality: Belgian Civil State: Married, 2 children Address: Begijnenhof 12, 6584 CW Molenhoek, The Netherlands Telephone: 0031-24-361 68 72 Fax: 0031-24-361 93 48 e-mail: e.levtchenko@cukz.umcn.nl Language Knowledges Russian: mother tongue Dutch: very good English: very good French: very good German: notion Basic Education 1972-1982: Secondary School with English Option in Moscow, diploma cum laude University Education 1982-1988: Russian Medical University Obtained certificate/diploma: MD cum laude Thesis: "Specific aspects of diabetes mellitus in children" 1988-1990: Paediatrics Research Institute of Academy of Medical Science - Moscow Staff Physician Narrow Specialisation in Paediatric Nephrology 1990-1991: Paediatrics Research Institute of Academy of Medical Science - Moscow Nephrology Department Postgraduate student with research object: "The role of lipids in the progress of kidney diseases" 1993-1997: Free University Brussels: Assistant in Department of Paediatrics 1998 (jan.-sept.) Assistant in Department of Paediatrics, UZA, Antwerpen 1998 - 2000 Fellow in Department of Paediatric Nephrology, UMC St. Radboud, Nijmegen sept.1999 receiving of diploma "physician-specialist in paediatrics" 2000 (oct - now) Paediatric Nephrologist, University Medical Centre St Radboud, Nijmegen, The Netherlnads Other Experience 1986-1987: WE-nurse in the department of neonatology and maternity Other post-graduate education 1991-1993: Free University of Brussels (VUB) - Belgium Postgraduate Course of Medical and Pharmacological Research. Thesis: Investigation of Proinsulin in Isolated Human ß-Cells and Human Pancreatic Extracts Obtained diploma: Master of Medical and Pharmaceutical Research 1995-1996: Postgraduate Course "Brevet: Urgentie geneeskunde" 09-13/03/1998 Peritoneal Dialysis University, Academic Medical Centrum, Amsterdam 23-25/04/1999 Dialysis Academy, University of Gent 07-18/06/1999 Molecular Biology and Recombonant DNA technology, University of Utrecht 25-27/01/2000 Course of "Nederlandse Vereniging voor Hemostase en Trombose" Houthalen 31/08-1/09/2000 Boerhaave course Practical Nephropathology Leiden Publications 1. The evolution of the nephrotic syndrome depending on the age of the child at the start of the disease. 2. Levtchenko E, Naumova V Pediatric Nephrology Problems, 1990, 29-38 2. Apoproteines A & B of blood in the glomerulonephrite of children. Levtchenko E, Naumova V Laboratory Methods in Nephrology, 1991, 50-58 3. Criteria of Nephrotic Syndrome activity of children depending on their age. Levtchenko E, Naumova V Published in the minutes of the 5th nephrologic congress in Frunze-1990, p.23 4. Erlichiosis in Belgium. Pierard D, Levtchenko E, Dawson JE, Lauwers S Lancet, 1995, 346: 1233-1234. 5. Exogenous surfactant therapy for status asthmaticus. Levtchenko E, Ramet J Eur.J. Pediatr, 1996, 156. 6. Urinaire ß2-microglobuline bepalingen bij jonge kinderen met acute pyelonefritis Levtchenko E, De Bock S, De Schepper J Mini Acta, 1996: 129. 7. Groeihormoontherapie bij chronisch nierlijden. E.Levtchenko, J.De Schepper, K.Boven, K.Van Hoeck Mini Acta, 1998, 30 (2): 92-93. 8. Nutritional value of an "anti-regurgitation" formula E.Levtchenko, B.Hauser, Y.Vandenplas Acta Gastro-Enterologica belgica, 1998, LX1: 285-287. 9. Bowel perforation due to hypotension in an infant with Prune Belly Syndrome undergoing peritoneal dialysis. E.Levtchenko, S.O.Pardede, L.Monnens Peritoneal Dialysis International, 1999, 19: 492. 10.Autosomal recessive inheritance of von Willebrand factor-cleaving protease deficiency.. te Loo DMWM, Levtchenko E, Furlan M, Roosendaal G, van den Heuvel L Pediatric Nephrology, 2000, 14: 762-765. 11.The molecular basis of Dutch infantile nephropatic cystinosis patients. Heil S, Levtchenko E, Monnens L, Trijbels F, Van der Put N, Blom H Nephron, 2001, 89: 50-55. 12. Attitude of Belgian pediatricians toward the diagnosis and treatment of acute pyelonephritis in Belgium. Levtchenko EN, Ham HR, Levi J, Piepsz A Pediatr Nephrol, 2001, 16:113-115. 13. Role of Tc-99m DMSA scintigraphy in the diagnosis of culture negative pyelonephritis. Levtchenko EN, Lahy C, Levy J, Ham HR, Piepsz A Pediatr Nephrol, 2001, 16: 503-506. 14. Treatment of children with acute pyelonephritis: a prospective randomised study. Levtchenko EN, Lahy C, Levy J, Ham HR, Piepsz A Pediatr Nephrol, 2001, 16: 878-884. 15. Negligible urinary cysteamine loss in cystinosis patients with Fanconi syndrome. Levtchenko EN, de Graaf-Hees A, Blom HJ, Monnens LAH Clinical Nephrology, 57: 349-351, 2002. 16. Indicaties en complicaties van nierbiopsie op kinderleeftijd. Levtchenko E, van Die C, van Collenburg JJM Tijdschrift Kindergeneeskd 2001, 69 (6): 218-221. 17. Follow-up and treatment of adults with nephropathic cystinosis in the Netherlands. Geelen JM, Monnens LAH, Levtchenko EN Nephrology Dialysis, Transplantation, 17: 1-5, 2002. 18. WT-1 and NPHS2 mutations analysis in patients with steroid resistant focal segmental glomerulosclerosis. Löwik M, Levtchenko E, Monnens L, van den Heuvel L Clinical Nephrology 59: 143-146, 2003. 19 .Enalapril diminishes albuminuria in patients with cystinosis. Levtchenko E, Blom H, Wilmer M, vanden Heuvel L, Monnens L Clinical Nephrology 60: 386-389, 2003. 20. Effective chemical preservation of morphology of urinary erythrocytes. Komarova O, Van Der Meer W, Levtchenko E, Monnens L. Pediatr Nephrol. 2003, 7:665-6. Epub 2003 May 14. 21. Distinction between Liddle syndrome and apparent mineralocorticoid excess. Monnens L, Levtchenko E Pediatr Nephrol. 2003 Nov 19 [Epub ahead of print]. 23. From gene to disease; SLC3A1, SLC7A9 and cystinuria Geelen J, Levtchenko E, Monnens L Dutch Journal of Medicine 2003, 147(25): 1242-1243. 24. From gene to disease; cystinosis. Levtchenko E, Wilmer M, de Graaf-Hess A, van den Heuvel L, Blom H, Monnens L Accepted in Dutch Journal of Medicine, 2004 25. Comparison of cystine determination in mixed leukocytes versus polymorphonuclear leukocytes for diagnosis of cystinosis and monitoring of cysteamine therapy. Levtchenko E, de Graaf-Hess A, Wilmer M, van den Heuvel L, Monnens L, Blom H Submitted, 2004 Presentations at Congresses 1. Trois cas de "pseudo"-obstruction intestinale B.Hauser, E.Levtchenko, A.Vanderfaillie, M.Scaillon, Y.Vandenplas, S.Cadranel Oral presentation during 10e Verjaardag van BGPGN, 22/10/94, Brussels. 2. Analgesienoden volgens ventilatie modes. J.Ramet, E. Levtchenko Oral presentation during the 23th annual meeting of "Belgische vereniging voor kindergeneeskunde"; 17-18/03/1995, Brussels 3. Incidentie van intracraniële bloeding bij kinderen met schedel-fracturen. E.Levtchenko, S.Hachimi-Idrissi, B.Desprechins, J.Ramet Poster during the 23th annual meeting of "Belgische vereniging voor kindergeneeskunde"; 17-18/03/1995, Brussels. Published in Mini Acta, 1995: 62. 4. Decrease of the sedation requirements with pressure regulated volume control ventilation J.Ramet, S.Hachimi-Idrissi, E.Levtchenko Poster during 25th International symposium on intensive care and emergency medicine, 21-24/03/1995, Brussels. 5. First case of human ehrlichiosis in Belgium. E.Levtchenko, D.Pierard, J.Van der Werff ten Bosch, P.Bollen, J.De Schepper, S.Lauwers. Oral presentation during 24th annual meeting of "Belgische vereniging voor kindergeneeskunde"; 22-23/03/1996, Spa. 6. Chronic subdural haematoma in infants: a sign of the whiplash shaken baby syndrome ? E.Levtchenko, I.Rayen, S.Rosseneu, D.Denolf, J.Marchand, L.Demeirleir, J.D'Haens, A.Lampo, J.De Schepper. Oral presentation during 24th annual meeting of "Belgische vereniging voor kindergeneeskunde"; 22-23/03/1996, Spa. 7. Serum apoproteins in nephrotic children. E.Levtchenko, D.Matkerimov, J.De Schepper, T.Sergeeva Poster during the 30th Annual Meeting of the European Society for Paediatric Nephrology, August 29 - September 1, 1996, Lausanne. Published in Pediatric Nephrology, 1996, 10: C142. 8. Randomised treatment trial of children with acute pyelonephritis. E.Levtchenko, C.Lahy, M.Verboven, J.Levy, H.Ham, A.Piepz Poster during 31st Annual Meeting of the European Society for Paediatric Nephrology, September 27-30, 1997, Athens. Published in Pediatric Nephrology, 1997, 11: C 57. 9. Results of glucose tolerance testing in children recovering from hemolytic-uremic syndrome. E.Levtchenko, J.De Schepper, J.Ramet, Y.Vandenplas Poster during 31st Annual Meeting of the European Society for Paediatric Nephrology, September 27-30, 1997, Athens. Published in Pediatric Nephrology, 1997, 11: C 83. 10. Acute pyelonephritis without positive urine culture. E.Levtchenko, C.Lahy, M.Verboven, J.Levy, H.Ham, A.Piepsz Poster during 26th "Belgische vereniging voor kindergeneeskunde". Published in Mini Acta, 1998, 84. 11. Etude randomisée du traitement des pyelonéphrites aigues chez l'enfant. C.Lahy, E.Levtchenko, M.Verboven, J.Levy, H.Ham, A.Piepsz Poster during 26th "Belgische vereniging voor kindergeneeskunde". Published in Mini Acta, 1998, 85. 12. Longitudinal changes in peritoneal equilibration test (PET) characteristics in very young children. K.Boven, N.De Brabander, E.Levtchenko, K.Van Hoeck Poster during 11 th Congress of the International Pediatric Nephrology Association, September 12-16, 1998, London. Published in Pediatric Nephrology, 1998, 12: C209. 13. Attitude of Belgian paediatricians to diagnosis and treatment of acute pyelonephritis. E.Levtchenko, J.Levy, H.Ham, A.Piepsz Poster during 27th "Belgische vereniging voor kindergeneeskunde".19-20/03/99, Brussels Published in Journal du pediatre Belge, 134. 14. To treat or not to treat? E. Levtchenko, L. Monnens Oral Presentation during 30 Conference of European Working Group on Psychological Aspects of Children with Chronic Renal Failure. Nijmegen, May 26-29, 1999 15. Cystinose sans accumulation de cystine en leucocytes. E.Levtchenko, H. Blom, A. Van de Vlucht, A. De Graaf, L.Monnens Presentation during Seminaire de Nephrologie Pediatrique, 22-23/03/99, Parijs. 16. National audit: diagnosis and treatment of acute pyelonephritis in Belgium. E.Levtchenko, J.Levy, H.Ham, A.Piepsz Poster during de 33th Annual Meeting of the European Society for Paediatric Nephrology, September 3-5, 1999, Praeg. Published in Pediatric Nephrology, 1999, 11: P111. 17. Hereditary thrombotic Thrombocytopenic purpura due to Von Willebrand Factor protease deficiency. E. Levtchenko, M. te Loo, M.Furlan, L.van den Heuvel, L. Monnens Poster during 64 meeting of NVVN Gent, Oktober 9, 1999. 18. Cystinose sans accumulation de cystine en leucocytes. E.Levtchenko, H. Blom, A. Van de Vlucht, A. De Graaf, L.Monnens Oral presentation during Seminaire de Nephrologie Pediatrique, 22-23/03/99, Parijs. 19. Molecular basis of cystinosis in eleven Dutch patients. S.G.Heil, L.Monnens, E.Levtchenko, P. van der Put, H.Blom Oral presentation during 65 meeting of NVVN Utrecht, Januaru 15, 2000. 20. Treatment of children with acute pyelonephritis: a prospective randomized study. E.Levtchenko, C.Lahy, J.Levy, M.Verboven, H.Ham, A.Piepsz Oral presentation during de 34th Annual Meeting of the European Society for Paediatric Nephrology, June 18-20, 2000, Helsinki. 21. Treatment of children with acute pyelonephritis: a prospective randomized study. A.Piepsz, E.Levtchenko, C.Lahy, J.Levy, M.Verboven, H.Ham Oral presentation during European Association of Nuclear Medicine Congress September 2-6, 2000, Paris. 22. Renal graft removal after failed transplantation - a more aggressive approach? F.Zarouali, E.Levtchenko, M.Cornelissen, L.Monnens Poster during First Congress of the International Pediatric Transplant association. Augustus 23-25, 2000, Venice. 23. Verwijderen van falende transplantaatnier - een meer aggressieve aanpak? E.Levtchenko, F.Zarouali, M.Cornelissen, L.Monnens Poster during Wetenschapsdag 2000, UMC St.Radboud, October 27, 2000, Nijmegen Poster during 22 Annual Meeting of Dutch Society of Pediatrics, November 1-3, 2000, Veldhoven 24. Negligible urinary cysteamine loss in cystinosis patients E.Levtchenko, L. Monnens, H.Blom Oral presentation during Autumn symposium of Dutch Society of Hereditary metabolic disease, October 8-10, 2000, Leeuwenhorst, Noordwijkerhout 25. Treatment of children with acute pyelonephritis: a prospective randomized study. E.Levtchenko, C.Lahy, J.Levy, M.Verboven, H.Ham, A.Piepsz Oral presentation during 34th Annual Meeting of the European Society for Paediatric Nephrology, June 18-20, 2000, Helsinki. 25. Follow-up en behandeling van volwassene cystinose patiënten in Nederland. J.Geelen, E.Levtchenko, L.Monnens Oral presentation during Autumn symposium of Dutch Society of Hereditary metabolic disease, October 8-10, 2000, Noordwijkerhout 26. Revealing the molecular basis of nephropathic infantile cystinosis in Dutch patients. S.G.Heil, E.Levtchenko, L.A.H.Monnens, F.J.M.Trijbels, N.M.J. van de Put, H.J.Blom Poster during Spring symposium of Dutch Society of Clinical Chemistry Lunteren, April 11, 2001 27. Follow-up and treatment of adults with nephropathic cystinosis in the Netherlands. E.Levtchenko, J.Geelen, L.Monnens Poster during 12th Congress of the International Pediatric Nephrology Assiciation, Seattle September1-5, 2001. Published in Pediatric Nephrology, 2001, 16: C96. 28. Low urinary cysteamine excretion in cystinosis patients. E.Levtchenko, A.De Graaf, L.Monnens, H.Blom Poster during 12th Congress of the International Pediatric Nephrology Assiciation, Seattle September1-5, 2001. Published in Pediatric Nephrology, 2001, 16: C96. 29. Cystinosis: pitfalls in diagnosis and treatment. H.J.Blom, E.Levtchenko, A. De Graaf, S.G.Heil, L.A.H.Monnens Poster during 13th ESGLD Workshop Woudschoten, September 20-23, 2001 30. Cystinebepaling bij cystinose patiënten: therapeutische consenquenties afhankelijk van het celtype. E. Levtchenko, A. De Graaf, L.Monnens, H.Blom Poster during 23 Annual Meeting of Dutch Society of Pediatrics Veldhoven, November 7-9, 2001 Published in Tijdschrift Kindergeneeskd 2001, 5A: 13 30. Pitfalls in cystine measurements: therapeutic consequences for cystinosis patients. E. Levtchenko, A. De Graaf, L.Monnens, H.Blom Poster during meeting of Dutch Society of Nephrology Groningen, November 24, 2001 31. WT-1 and NPHS2 mutation analysis in patients with non-familial steroid-resistant focal segmental glomerulosclerosis. M.M. Löwik, E.N. Levtchenko, L.A.H. Monnens, L.P.W.J. van den Heuvel Poster during Nederlandse Nefrologie Dagen 2002 Noordwijkerhout, April 4-5, 2002 32. Can we prevent dialysis-associated morbidity by using non-invasive blood volume monitoring? E. Levtchenko, D. Creemers, H. Van Lier, D. Van Schaijk, I. Van Rijbroek, C. Schröder Poster during the 36th Annual Meeting of the European Society for Paediatric Nephrology, September 20-23, 2002, Bilbao. Published in Pediatric Nephrology, 2002, 17: C131. 33. Enalapril diminishes albumin excretion in patients with cystinosis. E. Levtchenko, M.Wilmer, H.Blom, L. van den Heuvel, L.Monnens Oral presentation during 36th Annual Meeting of the European Society for Paediatric Nephrology, September 20-23, 2002, Bilbao. Published in Pediatric Nephrology, 2002, 17: C49. 34. Use of non-invasive blood volume monitoring by hematocrit for prevention of dialysis associated morbidity in children. Levtchenko E, Creemers D, Van Lier H, Van Schaijk D, Van Rijbroek I, Schröder C Poster during ASN Renal week 2002 Philadelphia Oktober 30-November 4, 2002. Published in J Am Soc Nephrol 13: 580A, 2002 35. Use of non-invasive blood volume monitoring by hematocrit, cGMP and inferior vena cava diameter for determination of dry weight in children on hemodialysis. Levtchenko E, Creemers D, van Schaijk D, Rijbroek I, Schr der C. Poster during World Congress of Nephrology. Price of 20% best abstracts. Berlijn, Juni 8-12, 2003 34. Effect of carnitine supplementation on muscle function in cystinotic patients with Fanconi syndrome. Levtchenko E, de Jong J, Ruitenbeek W, de Knecht S, Monnens L Poster during World Congress of nephrology Berlijn, Juni 8-12, 2003 35. Studies in fibroblasts: a usefull tool towards the understanding of the pathogenesis of cystinosis. Levtchenko E, Wilmer M, van den Heuvel L, Blom H, Monnens L Poster during 25 congress of Dutch Society of Pediatrics Veldhoven, November 5-7, 2003. 36. The importance of WT1-gene molecular analysis in patients with non-familial steroidresistant nephrotic syndrome Löwik M, Levtchenko E, van den Heuvel L, Monnens L Poster during 25 congress of Dutch Society of Pediatrics Veldhoven, November 5-7, 2003. 37. ATP depletion in cultured cystinotic fibriblasts Levtchenko E, Koenderink J, Wilmer M, van den Heuvel L, Blom H, Monnens L Poster during ASN Renal Week 2003 San-Diego, November 14-18, 2003 Membership in societies 1. Netherlands Society of Nephrology 2. Netherlands Society of Paediatrics 3. Belgian Society of Paediatrics 4. European Society for Paediatric Nephrology 5. Belgian Society of Nephrology 6. International Paediatric Nephrology Association 7. American Society of Nephrology